JQKD82 (JADA82) trihydrochloride 是一种细胞通透性和选择性 KDM5 抑制剂。JQKD82 trihydrochloride 增加 H3K4me3，可用于多发性骨髓瘤的研究。
货号:ajcx38402
CAS:N/A
分子式:C27H43Cl3N4O5
分子量：610.01
溶解度:Methanol : 250 mg/mL (409.83 mM; Need ultrasonic)|DMSO : 50 mg/mL (81.97 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma[1].

JQKD82 (0.3 μM; 24 hours) trihydrochloride causes an increase in the global H3K4me3 level of MM.1S cells[1].JQKD82 (0.1-10 μM; day 1-day 5) trihydrochloride inhibits the growth of MM.1S cells in a dose- and time-dependent manner. JQKD82 trihydrochloride is potent at eliciting growth suppression in MM.1S cells (IC50=0.42 μM)[1].JQKD82 (1 μM; 24 hours) trihydrochloride induces G1 cell-cycle arrest by 48 hours in MM.1S and MOLP-8 cells[1].

JQKD82 (50-75 mg/kg; i.p.; twice a day for 3 weeks) trihydrochloride has anti-multiple myeloma activity[1].JQKD82 trihydrochloride displays an increase in H3K4me3 levels and results in a dramatic reduction of MYC immuno-staining in vivo[1].

[1]. Jun Qi, et al. Histone demethylase 5 inhibitors and uses thereof. WO2020033377A1.