GSK8612 是具有高度选择性的，TBK1 的强效抑制剂，对重组TBK1 的 pIC50 值为 6.8。
货号:ajcx38742
CAS:2361659-62-1
分子式:C17H17BrF3N7O2S
分子量：520.33
溶解度:DMSO : ≥ 125 mg/mL (240.23 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1[1].

GSK8612 inhibits toll-like receptor (TLR)3-induced IRF3 phosphorylation in Ramos cells and type I IFN secretion in primary human mononuclear cells. In THP1 cells, GSK8612 is able to inhibit secretion of IFNβ in response to dsDNA and cGAMP, the natural ligand for STING[1].

[1]. Thomson DW, et al. Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor. ACS Med Chem Lett. 2019 Mar 11;10(5):780-785.

Protocol:

TBK1 6.8(pIC50)