DSP-1053 是一种苄基哌啶衍生物，一种有效的血清素转运蛋白 (SERT) 抑制剂，Ki 值为 1.02 nM。DSP-1053 显示部分 5-HT1A 受体激动活性，Ki 值为 5.05 nM。DSP-1053 具有抗抑郁活性。
货号:ajcx38744
CAS:1176326-76-3
分子式:C26H32BrNO4
分子量：502.44
溶解度:DMSO : 100 mg/mL (199.03 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

DSP-1053, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 shows partial 5-HT1A receptor agonistic activity with a Ki of 5.05 nM. DSP-1053 has antidepressant activity[1].

[1]. Yoshinaga H, et al. Discovery of DSP-1053, a novel benzylpiperidine derivative with potent serotonin transporter inhibitory activity and partial 5-HT1A receptor agonistic activity. Bioorg Med Chem. 2018 May 1;26(8):1614-1627.

Protocol:

5-HT1AReceptor 5.05nM(Ki)