RR-11a analog 是一种有效且不可逆的 Schistosoma mansoni legumain 抑制剂。其 IC50 为 31 nM。RR-11a analog 是 aza-Asn 的衍生物和 aza-peptide Michael 的受体。
货号:ajcx39604
CAS:685543-66-2
分子式:C22H29N5O8
分子量：491.49
溶解度:DMSO : 125 mg/mL (254.33 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor[1][2].

RR-11a analog has a half-live of 3-10 min[2].

[1]. GÖtz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32.
[2]. Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92.