RB-90740 is an aromatic mono-N-oxide bioreductive drug, which showed considerably greater toxicity towards hypoxic verses aerobic mammalian cells in vitro. The differential in concentration required to give the same level of cell killing under these conditions ranges from 3.5 in a human bronchio-alveolar tumor cell line up to 120 in a rodent cell line defective in the repair of DNA strand breaks. The ability of RB 90740 to cause DNA strand breaks under hypoxic conditions was confirmed by alkaline sucrose gradient and pulsed field gel electrophoresis techniques. References: Urquiola C, Vieites M, Torre MH, Cabrera M, Lavaggi ML, Cerecetto H, GonzA!lez M, Cerain AL, Monge A, Smircich P, Garat B, Gambino D. Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs. Bioorg Med Chem. 2009 Feb 15;17(4):1623-9. doi: 10.1016/j.bmc.2008.12.064. Epub 2009 Jan 3. PubMed PMID: 19162490.

纯度：≥98%

CAS：108307-65-9