SOS1-IN-1是SOS1的一个抑制剂。
货号:ajcx12390
CAS:4551-00-2
分子式:C22H15NO2
分子量：325.36
溶解度:DMSO: 12.5 mg/mL (38.42 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SOS1-IN-1 is a SOS1 inhibitor.

The growth inhibitory rate (IR)=(average OD value in the control group-average OD value in the treatment group)/average OD value in the control group×100% are compared. Treatments with SOS1-IN-1 at 40 μM and NSC-658497 at 30 μM result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK[1].

[1]. ARYL SULFONOHYDRAZIDES. WO 2016077793A1.

Protocol:

Cell experiment:	MIA paca-2 cells (KRAS G12 C) are subjected to a 3-day proliferation assay following treatment with SOS1-IN-1 (NSC-70220: 40 μM), treatment with NSC-658497 (30 μM) and treatment with a combination of SOS1-IN-1 (40 μM) and NSC-658497 (30 μM). DMSO is used as the negative control[1].
参考文献: [1]. ARYL SULFONOHYDRAZIDES. WO 2016077793A1.