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RO 4938581
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RO 4938581图片
规格:98%
分子量:352.14
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
RO4938581是一种有效的,选择性的GABAAα5反向激动剂,对GABAAα5β3γ2a的Ki值为4.6nM,对α1β3γ2a,α2β3γ2a,α3β3γ2a的亲和性相对较低,Ki值分别为174,185和80nM;RO4938581可用于认知功能障碍的研究。
货号:ajcx12544
CAS:883093-10-5
分子式:C13H8BrF2N5
分子量:352.14
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.

RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively)[1].

RO 4938581 (0.3-1 mg/kg, p.o.) reverses a working memory impairment induced by scopolamine the delayed match to position (DMTP) task and a spatial learning impairment induced by diazepam (RO 4938581; 1-10 mg/kg, po)[1].

[1]. Knust H, et al. The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4.