CARM1-IN-1盐酸盐是CARM1高效选择性抑制剂，IC50值为8.6uM，对PRMT1和SET7抑制活性很抵。
货号:ajcx13548
CAS:N/A
分子式:C26H22Br2ClNO3
分子量：591.72
溶解度:DMSO : ≥ 38 mg/mL (64.22 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 >600 uM). IC50 value: 8.6 uM [1]Target: CRAM1 inhibitorin vitro: CARM1-IN-1 displays high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, CARM1-IN-1 shows a significant dose-dependent reduction of the PSA promoter activity.

[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.