RORγt Inverse agonist 3 是一种高效选择性的，有口服活性的视黄酸受体相关孤儿受体 RORγ 的逆向激动剂，对 hRORγ 和人类 IL-17 细胞 RORγt 作用的 EC50 值分别为 0.22 μM 和 0.15 μM。
货号:ajcx14110
CAS:N/A
分子式:C29H31Cl2N5O4S
分子量：616.56
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

RORγt Inverse agonist 3 is a potent, selective and orally active RORγ inverse agonist, with EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively[1]. EC50: 0.22 μM (hRORγ), 0.15 μM (RORγt, human IL-17 cells)[1]

[1]. Amaudrut J, et al. Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1799-1806.