γ-Secretase modulator 4 是一种有效的 γ- 分泌酶调节剂 (γ-secretase)，在人类和小鼠中降低 Aβ42 产生的 IC50 值分别为 0.014 μM 和 0.017 μM。
货号:ajcx14180
CAS:N/A
分子式:C23H19FN4O2
分子量：402.42
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.014 μM and 0.017 μM in human and mouse, respectively[1]. IC50: 0.014 μM (Aβ42, human), 0.017 μM (Aβ42, mouse)[1]

[1]. Bischoff FP, et al. Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1737-1745.