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Tyrphostin AG1433
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tyrphostin AG1433图片
规格:98%
分子量:266.29
包装与价格:
包装价格(元)
5mg电议
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500mg电议

产品介绍
Tyrphostin AG1433 (SU1433) 是酪氨酸激酶抑制剂。Tyrphostin AG1433 还是一种选择性的 PDGFRβ 和 VEGFR-2 (Flk-1/KDR) 抑制剂,IC50 分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433 可防止血管形成。
货号:ajcx16402
CAS:168835-90-3
分子式:C16H14N2O2
分子量:266.29
溶解度:DMSO: 62.5 mg/mL (234.71 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation[1][2][3][4].


[1]. Serban F, et al. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33. [2]. Strawn LM, et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56(15):3540-5. [3]. Kim TS, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3(11-12):752-62. [4]. Kroll J, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997 Dec 19;272(51):32521-7.