JNJ-46281222 是选择性代谢型谷氨酸 2 (mGlu2) 高效 PAM (正构变构调节剂)，具有纳摩尔摩尔亲和力(Kd=1.7 nM) 和高调节效能 (pEC50 = 7.71) 的高效 PAM (正构变构调节剂)。
货号:ajcx16546
CAS:1254980-38-5
分子式:C23H25F3N4
分子量：414.47
溶解度:DMSO: 62.5 mg/mL (150.79 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1].

[1]. Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.Br J Pharmacol. 2016 Feb;173(3):588-600.