4-Bromo-3-hydroxybenzoic acid 是一种 Brocresine 的代谢产物，也是一种组氨酸脱羧酶 (HDC) 抑制剂，对大鼠胎儿和大鼠胃 HDC 的 IC50 均为 1 mM。4-Bromo-3-hydroxybenzoic acid 还可以在体外抑制猪肾脏和大鼠胃粘膜中的芳香族 L-氨基酸脱羧酶 (aromatic-L-amino acid decarboxylase)，两种酶的 IC50 均为 1 mM。
货号:ajcx16690
CAS:14348-38-0
分子式:C7H5BrO3
分子量：217.02
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes[1][2].

[1]. Ellenbogen L, et al. Studies on the inhibition of histidine decarboxylase, aromatic-L-amino acid decarboxylase and acid secretion by brocresine and its metabolites. Biochem Pharmacol. 1973 Apr 15;22(8):939-47. [2]. Qian S, et al. Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. J Mol Neurosci. 2019 Mar;67(3):411-417.