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(S)-(-)-Linoleyl-1'-Hydroxy-2'-Propylamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-(-)-Linoleyl-1'-Hydroxy-2'-Propylamide图片
规格:98%
分子量:337.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group.
货号:ajcx17744
CAS:N/A
分子式:C21H39NO2
分子量:337.5
溶解度:DMF: 11 mg/ml,DMSO: 5 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning. LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10 and 25 μM for CB1 and CB2, respectively). It also inhibits fatty acid amide hydrolase (FAAH; Ki = 9 μM) and is hydrolyzed by FAAH, and inhibits voltage-gated K+ channels. (S)-(-)-Linoleyl-1'-hydroxy-2'-propylamide is a homolog of LOEA, characterized by the addition of an (S)-α-methyl group at the methylene carbon adjacent to the amide nitrogen. A similar modification of arachidonoyl ethanolamide to produce S-1 methanandamide results in a diminished affinity for the CB receptor but greatly improved metabolic stability to aminopeptidase hydrolysis. The physiological actions of this compound have not been evaluated.