| 包装: | 1mg |
| 规格: | 98% |
| 市场价: | 3096元 |
| 分子量: | 3039.4 |
Background:
Secretin is an endogenous 27-amino acid gastrointestinal hormone and neuropeptide that regulates secretion from the stomach, pancreas, and liver. It belongs to the secretin/glucagon superfamily of peptides, which includes glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . Secretin dose-dependently increases somatostatin release from primary human antral cells in vitro. In vivo, secretin dose-dependently increases the volume of pancreatic secretion as well as inhibits gastric acid secretion induced by gastrin I in rats when administered at a dose of 100 pmol/kg per h. Secretin (40 μg/kg, i.v.) increases the number of neurons expressing c-fos in the central amygdala and area postrema in rats.
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