ARN726 是一种有效的 NAAA（N-酰基乙醇胺酸酰胺酶）抑制剂，IC50 为 0.073 μM.
货号:ajcx19312
CAS:1628343-77-0
分子式:C14H24N2O3
分子量：268.4
溶解度:DMF: 33 mg/ml,DMSO: 33 mg/ml,Ethanol: 33 mg/ml,Ethanol:PBS (pH 7.2) (1:4): 0.20 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ARN726 is an inhibitor of N-acylethanolamine acid amidase (NAAA; IC50s = 27 and 63 nM for the human and rat enzyme, respectively).1 It is selective for NAAA over fatty acid amide hydrolase (FAAH) and acid ceramidase (IC50s = >100 and 12.5 μM, respectively), as well as a panel of 28 lipid metabolism- and inflammation-related enzymes at 10 μM. ARN726 (1-30 mg/kg) decreases lung myeloperoxidase activity and pleural exudate TNF-α levels in a mouse model of carrageenan-induced lung inflammation. It inhibits NAAA and reverses complete Freund's adjuvant-induced decreases in palmitoyl ethanolamide and oleoyl ethanolamide levels in inflamed paw tissue in a rat model of arthritis.2

参考文献
1. Ribeiro, A., Pontis, S., Mengatto, L., et al. . Chem. Biol. 10, 1838-1846 (2015).
2. Bonezzi, F.T., Sasso, O., Pontis, S., et al. An important role for N-acylethanolamine acid amidase in the complete Freund's adjuvant rat model of arthritis. J. Pharmacol. Exp. Ther. 356(3), 656-663 (2016).