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Histone H3K9Me2(3-17)(human,mouse,rat,porcine,bovine)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Histone H3K9Me2(3-17)(human,mouse,rat,porcine,bovine)(trifluoroacetate salt)图片
包装:1mg
规格:98%
市场价:3689元
分子量:1614.9

产品介绍
C67H123N25O21.XCF3COOH
货号:ajcx19478
CAS:N/A
分子式:C67H123N25O21.XCF3COOH
分子量:1614.9
溶解度:Water: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Histone H3K9Me2 (3-17) is a peptide fragment of histone H3 that corresponds to amino acid residues 4-18 of the human histone H3 sequence. Dimethylation of histone H3 at lysine 9 is associated with transcriptional repression.1 Heterochromatin protein 1-α (HP1-α), HP1-β, and HP1-γ selectively bind histone H3 N-terminal peptides containing dimethylated lysine 9 over unmodified lysine 9.2 In mouse embryos, maternal chromatin containing H3K9Me2 is bound by PGC7, which preserves DNA methylation and protects 5-methylcytosine from conversion to 5-hydroxymethylcytosine.3

参考文献
1. Lienert, F., Mohn, F., Tiwari, V.K., et al. Genomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells. PLoS Genet. 7(6), e1002090 (2011).
2. Lachner, M., O'Carroll, D., Rea, S., et al. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410(6824), 116-120 (2001).
3. Nakamura, T., Liu, Y.-J., Nakashima, H., et al. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature 486(7403), 415-419 (2012).