A neuropeptide with diverse biological activities
货号:ajcx20946
CAS:N/A
分子式:C16H6BrD7O2
分子量：324.2
溶解度:DMF: 50 mg/ml,DMSO: 25 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): .05 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(R)-Bromoenol lactone-d₇((R)-BEL-d₇) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of (R)-BEL by GC-or LC-mass spectrometry (MS). The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.¹The calcium-independent phospholipase A₂(iPLA₂) are a PLA₂subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of iPLA₂γ. Unlike (S)-BEL, (R)-BEL does not inhibit iPLA₂β except at high doses of 20-30 µM.²(R)-BEL inhibits human recombinant iPLA₂γ with an IC₅₀of approximately 0.6 µM.

1.Balsinde, J., Balboa, M.A., Insel, P.A., et al.Regulation and inhibition of phospholipase A2Annual Reviews of Pharmacology and Toxicology39175-189(1999) 2.Jenkins, C.M., Han, X., Mancuso, D.J., et al.Identification of calcium-independent phospholipase A2 (iPLA2)β, and not iPLA2γ, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cellsThe Journal of Biological Chemisty277(36)32807-32814(2002)