您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > 17-phenyl trinor Prostaglandin F2α-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
17-phenyl trinor Prostaglandin F2α-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17-phenyl trinor Prostaglandin F2α-d4图片
规格:98%
分子量:392.5
包装与价格:
包装价格(元)
25ug电议
50ug电议
100ug电议
1mg电议

产品介绍
An internal standard for the quantification of bimatoprost (free acid)
货号:ajcx21154
CAS:58976-50-4
分子式:C23H28D4O5
分子量:392.5
溶解度:DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): .5 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

17-phenyl trinor Prostaglandin F-d4(17-phenyl trinor PGF-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 17-phenyl trinor PGFby GC-or LC-mass spectrometry. 17-phenyl trinor PGFis a metabolically stable analog of PGFand is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF.1At the rat recombinant FP receptor expressed in CHO cells 17-phenyl trinor PGFinhibits PGFbinding with a Kiof 1.1 nM.2The isopropyl ester of 17-phenyl trinor PGF-d4is slightly better than PGFisopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.3


1.Balapure, A.K., Rexroad, C.E., Jr., Kawada, K., et al.Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptorBiochem. Pharmacol.38(14)2375-2381(1989) 2.Lake, S., Gullberg, H., Wahlqvist, J., et al.Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptorFEBS Letters355317-325(1994) 3.Stjernschantz, J., and Resul, B.Phenyl substituted prostaglandin analogs for glaucoma treatmentDrugs of the Future17691-704(1992)