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Bromocriptine-13C-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bromocriptine-13C-d3图片
规格:98%
分子量:658.6
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx21854
CAS:N/A
分子式:C31[13C]H37D3BrN5O5
分子量:658.6
溶解度:Chloroform: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Bromocriptine-13C-d3is intended for use as an internal standard for the quantification of bromocriptine by GC- or LC-MS. Bromocriptine is a dopamine receptor agonist (Kis = 1,659, 12.2, 12.2, 59.7, and 1,691 nM for dopamine D1, D2, D3, D4, and D5receptors, respectively).1It also binds to the serotonin (5-HT) receptor subtypes 5-HT1Aand 5-HT1D(Kis = 12.9 and 10.7 nM, respectively), as well as α1-adrenergic receptors (Kis = 1.12-4.17 nM).1,2Bromocriptine (5 mg/kg) restores locomotor activity, without inducing dyskinesia, in a macaque model of Parkinson's disease induced by MPTP.3Formulations containing bromocriptine have been used in the treatment of Parkinson's disease, hyperprolactinemia-associated dysfunctions, and acromegaly.


1.Kvernmo, T., HÄrtter, S., and BÜrger, E.A review of the receptor-binding and pharmacokinetic properties of dopamine agonistsClin. Ther.28(8)1065-1078(2006) 2.Millan, M.J., Maiofiss, L., Cussac, D., et al.Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypesJ. Pharmacol. Exp. Ther.303(2)791-804(2002) 3.Rouillard, C., BÉdard, P.J., and De Paolo, T.Effects of chronic treatment of MPTP monkeys with bromocriptine alone or in combination with SKF 38393Eur. J. Pharmacol.185(2-3)209-215(1990)