A neuropeptide with diverse biological activities
货号:ajcx21916
CAS:N/A
分子式:C59H104D3N2O21.NH4
分子量：1201.5
溶解度:Chloroform:Methanol:Water (2:1:0.1): Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C18 Ganglioside G_M3-d₃is intended for use as an internal standard for the quantification of ganglioside G_M3by GC- or LC-MS. Ganglioside G_M3is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.^1,2When used at a concentration of 20 μM, it suppresses angiogenesis and reduces endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.¹Furthermore, ganglioside G_M3has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.³[Matreya, LLC. Catalog No. 2052]

1.Mukherjee, P., Faber, A.C., Shelton, L.M., et al.Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1aJ. Lipid Res.49(5)929-938(2008) 2.Seyfried, T.N., and Mukherjee, P.Ganglioside GM3 is antiangiogenic in malignant brain cancerJ. Oncol.961243(2010) 3.Kabayama, K., Sato, T., Saito, K., et al.Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistanceProc. Natl. Acad. Sci. USA104(34)13678-13683(2007)