An antibody-drug conjugate containing SN-38
货号:ajcx22098
CAS:N/A
分子式:C82H106N12O23.XC2H2Cl2O2
分子量：1627.8
溶解度:DMSO: >1mg/mL,Ethanol: >1mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 and a maleimidocaproyl linker.¹CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (K_d= 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC₅₀= 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.

1.Moon, S., Govindan, S.V., Cardillo, T.M., et al.Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapyJ. Med. Chem.51(21)6916-6926(2008)