An internal standard for the quantification of dronedarone
货号:ajcx22378
CAS:1329809-23-5
分子式:C31H38D6N2O5S.HCl
分子量：599.3
溶解度:Chloroform: Slightly soluble,Methanol: Slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Dronedarone-d₆is intended for use as an internal standard for the quantification of dronedarone by GC- or LC-MS. Dronedarone is an antiarrhythmic agent and a derivative of amiodarone .^1,2It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC₅₀s = 0.1 and 1 µM, respectively).²Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing.³Formulations containing dronedarone have been used in the treatment of atrial fibrillation.

1.Sun, W., Sarma, J.S., and Singh, B.N.Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart: Comparison with amiodaroneCirculation100(22)2276-2281(1999) 2.Guillemare, E., Marion, A., Nisato, D., et al.Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cellsJ. Cardiovasc. Pharmacol.36(6)802-805(2000) 3.Saengklub, N., Limprasutr, V., Sawangkoon, S., et al.Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillationExp. Anim.66(3)251-258(2017)