An internal standard for the quantification of eliglustat
货号:ajcx22404
CAS:1884556-84-6
分子式:C23H21D15N2O4.C4H6O6
分子量：569.7
溶解度:DMSO: soluble,Methanol: soluble,Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Eliglustat-d₁₅is intended for use as an internal standard for the quantification of eliglustat by GC- or LC-MS. Eliglustat is an inhibitor of glucosylceramide synthase (IC₅₀= 40 nM for inhibition of glucosylceramide production in K562 cells).¹It is selective for glucosylceramide synthase over α-glucosidase I and II, α-1,6-glucosidase, lysosomal glucocerebrosidase, non-lysosomal glucosylceramidase, sucrase, and maltase (IC₅₀s = >10 µM for all). It decreases cell surface levels of the gangliosides GM₁and GM₃in K562 and B16/F10 cells with IC₅₀values of 24 and 29 nM, respectively. Eliglustat (150 mg/kg per day) decreases glucosylceramide levels in the liver and lungs of D409V/null mice, a model of Gaucher disease. Formulations containing eliglustat have been used in the treatment of type 1 Gaucher disease.

1.McEachern, K.A., Fung, J., Komarnitsky, S., et al.A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher diseaseMol. Genet. Metab.91(3)259-267(2007)