A naturally occurring estrogen
货号:ajcx22444
CAS:N/A
分子式:C18H24O4.XH2O
分子量：304.4
溶解度:DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium).^1,2In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.^1,2

1.Coelingh Bennink, H.J.T., Holinka, C.F., and Diczfalusy, E.Estetrol review: Profile and potential clinical applicationsClimacteric.11(Suppl 1)47-58(2008) 2.Giretti, M.S., Guevara, M.M.M., Cecchi, E., et al.Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin CytoskeletonFront.Endocrinol.(Lausanne)5(80)1-8(2014)