A neuropeptide with diverse biological activities
货号:ajcx22860
CAS:N/A
分子式:C50H73N13O11.XCF3COOH
分子量：1032.2
溶解度:DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Lys-(Des-Arg⁹)-Bradykinin is a naturally occurring peptide agonist of the bradykinin B₁receptor (K_i= 0.12 nM in HEK293 cells expressing the human receptor).^1,2It is selective for bradykinin B₁over B₂receptors (IC₅₀= >30,000 nM in CHO cells expressing the human receptor).³Lys-(Des-Arg⁹)-Bradykinin increases both mRNA and protein levels of the B₁receptor in IMR-90 human lung fibroblasts in a concentration-dependent manner.⁴It induces contraction of isolated rabbit aorta (pD₂= 8.6).⁵Lys-(Des-Arg⁹)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.²

1.Bastian, S., Loillier, B., Paquet, J.L., et al.Stable expression of human kinin B1 receptor in 293 cells: Pharmacological and functional characterizationBr. J. Pharmacol.122(2)393-399(1997) 2.Drapeau, G., deBlois, D., and Marceau, F.Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kininsJ. Pharmacol. Exp. Ther.259(3)997-1003(1991) 3.Hess, J.F., Borkowski, J.A., Macneil, T., et al.Differential pharmacology of cloned human and mouse B2 bradykinin receptorsMol. Pharmacol.45(1)1-8(1994) 4.Schanstra, J.P., BataillÉ, E., Marin CastaÑo, M.E., et al.The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblastsJ. Clin. Invest.101(10)2080-2091(1998) 5.Rhaleb, N.E., Drapeau, G., Dion, S., et al.Structure-activity studies on bradykinin and related peptides: AgonistsBr. J. Pharmacol.99(3)445-448(1990)