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Miglitol-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Miglitol-d4图片
包装:1mg
规格:98%
市场价:4074元
分子量:211.3

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22952
CAS:N/A
分子式:C8H13D4NO5
分子量:211.3
溶解度:DMSO: soluble,Water: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Miglitol-d4is intended for use as an internal standard for the quantification of miglitol by GC- or LC-MS. Miglitol is an inhibitor of α-glucosidases (IC50s = 0.35, 0.11, 1.3, and 1.2 µM for human lysosomal α-glucosidase and rat sucrase, maltase, and isomaltase, respectively).1It is selective for human α- over β-glucosidase (IC50= 84 µM). Miglitol (10 mg/kg) decreases blood glucose levels in sucrose-loaded Goto-Kakizaki (GK) type 2 diabetic rats.2Dietary administration of miglitol (40 mg/100 g diet) for 8 weeks decreases changes in HbA1c levels compared with control rats fed a normal diet. Formulations containing miglitol have been used in the treatment of type 2 diabetes.


1.Kuriyama, C., Kamiyama, O., Ikeda, K., et al.In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell culturesBioorg. Med. Chem.16(15)7330-7336(2008) 2.Goda, T., Suruga, K., Komori, A., et al.Effects of miglitol, an α-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki ratsBr. J. Nutr.98(4)702-710(2007)