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N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine图片
规格:98%
分子量:464.4
包装与价格：
包装价格(元)
100ug电议
500ug电议

产品介绍
A microbial metabolite with anticancer activity
货号:ajcx23016
CAS:30414-15-4
分子式:C20H20N2O11
分子量：464.4
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine is a microbial metabolite and degradation product of the bacterial siderophore enterobactin that has been found inStreptomycesand has anticancer activity.1,2,3It inhibits invasion of 26-L5 murine colon cancer cells in a Matrigel? assay with an IC50value of 2.7 µM.1


1.Igarashi, Y., Iida, T., Fukuda, T., et al.Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces spJ. Antibiot. (Tokyo)65(4)207-209(2012) 2.O'Brien, I.G., Cox, G.B., and Gibson, F.Enterochelin hydrolysis and iron metabolism in Escherichia coliBiochim. Biophys. Acta237(3)537-549(1971) 3.Raines, D.J., Moroz, O.V., Blagova, E.V., et al.Bacteria in an intense competition for iron: Key component of the Campylobacter jejuni iron uptake system scavenges enterobactin hydrolysis productProc. Nat. Acad. Sci. USA113(21)5850-5855(2016)