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Repaglinide-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Repaglinide-d5图片
规格:98%
分子量:457.6
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
瑞格列奈-d5 (AG-EE 623ZW D5) 是氘标记的瑞格列奈。
货号:ajcx23414
CAS:1217709-85-7
分子式:C27H31D5N2O4
分子量:457.6
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 25 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Repaglinide-d5is intended for use as an internal standard for the quantification of repaglinide by GC- or LC-MS. Repaglinide is a metaglitinide antidiabetic agent that blocks ATP-dependent potassium (Kir6) channels in pancreatic β-cells (Kd= 0.42 nM for the sulphonylurea receptor SUR1 when co-expressed with Kir6.2).1In vivo, repaglinide lowers blood glucose in fasted rats and dogs (ED50s = 10 and 28.3 μg/kg, respectively).2Formulations containing repaglinide have been used to control blood sugar levels in patients with type 2 diabetes.


1.Hansen, A.M.K., Hansen, J.B., Carr, R.D., et al.Kir6.2-dependent high-affinity repaglinide binding to β-cell KATP channelsBr. J. Pharmacol.144(4)551-557(2005) 2.Mark, M., and Grell, W.Hypoglycaemic effects of the novel antidiabetic agent repaglinide in rats and dogsBr. J. Pharmacol.121(8)1597-1604(1997)