A mitochondrial uncoupler
货号:ajcx23470
CAS:2379550-82-8
分子式:C11H6F3N5O3
分子量：313.2
溶解度:DMF: 10 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SHS4121705 is an orally bioavailable mitochondrial uncoupler.¹It increases oxygen consumption rate in L6 rat myoblast cells with an EC₅₀value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).

1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitisJ. Med. Chem.63(11)6203-6224(2020)