An antibiotic and derivative of tunicamycin
货号:ajcx23680
CAS:N/A
分子式:C39H68N4O16 (for TunR2 16:0)
分子量：0
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TunR2 is an antibiotic and derivative of tunicamycin .¹It is active againstB. subtilis(MIC = 0.3 µg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. Unlike tunicamycin, TunR2 is non-toxic toS. cerevisiae(MIC = >10 μg/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared with tunicamycin.

1.Price, N.P., Hartman, T.M., Li, J., et al.Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of β-lactamsJ. Antibiot. (Tokyo)70(11)1070-1077(2017)