A polyketide macrolide with antimycobacterial and anticancer activities
货号:ajcx23874
CAS:N/A
分子式:C47H76O17
分子量：913.1
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Amycolatopsin C is a polyketide macrolide originally isolated fromAmycolatopsisthat has antimycobacterial and anticancer activities.¹It is active againstM. bovisandM. tuberculosis(IC₅₀s = 2.7 and 5.7 µM, respectively) but notB. subtilis,S. aureus,E. coli, orP. aeruginosa(IC₅₀s = >30 µM for all). Amycolatopsin C is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC₅₀s = 10 and 5.9 µM, respectively).

1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494J. Antibiot. (Tokyo)70(12)1097-1103(2017)