A fluorescent probe for in vivo tumor cell imaging
货号:ajcx23926
CAS:115970-66-6
分子式:C38H46ClN2O6S2•Na
分子量：749.4
溶解度:DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IR 783 is a heptamethine cyanine fluorescent probe forin vivoimaging of tumor cells.^1,2It displays excitation/emission maxima of 633/780 nm, respectively. IR 783 is transported into tumor cells, an effect that can be blocked by the organic anion transporting polypeptide (OATP) inhibitor sulfobromophthalein .¹In vivo, IR 783 (11.25 mg/kg) preferentially accumulates in tumor tissue in an ACHN kidney cancer mouse xenograft model.²It has been conjugated to polyethylenimines for tumor-specific gene delivery.³

1.Yuan, J., Yi, X., Yan, F., et al.Near?infrared fluorescence imaging of prostate cancer using heptamethine carbocyanine dyesMol. Med. Rep.11(2)821-828(2015) 2.Yang, X., Shao, C., Wang, R., et al.Optical imaging of kidney cancer with novel near-infrared heptamethine carbocyanine fluorescent dyesJ. Urol.189(2)702-710(2013) 3.De Los Reyes-Berbel, E., Salto-Gonzalez, R., Ortega-MuÑoz, M., et al.PEI-NIR heptamethine cyanine nanotheranostics for tumor targeted gene deliveryBioconjug. Chem.29(8)2561-2575(2018)