Cyclic di-UMP(sodium salt)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	600ug
规格:	98%
市场价:	2948元
分子量:	656.3

产品介绍

A pyrimidine-containing CDN
货号:ajcx23962
CAS:N/A
分子式:C18H20N4O16P2•2Na
分子量：656.3
溶解度:Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).¹It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .^1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling.

1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nucleotide signalsNature564(7747)194-199(2019) 2.Hall, J., Ralph, E.C., Shanker, S., et al.The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibitionProtein Sci.26(12)2367-2380(2017)