BX-320 是一种选择性的、ATP 竞争性的、口服活性的直接 PDK1 抑制剂，在直接激酶测定中其 IC50 为 30 nM。 BX-320 还诱导细胞凋亡。抗癌作用。
货号:ajcx24034
CAS:702676-93-5
分子式:C23H31BrN8O3
分子量：547.5
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

BX-320 is an inhibitor of the serine/threonine kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1; IC₅₀= 30 nM).¹It is selective for PDK1 over a panel of 10 additional kinases (IC₅₀s = >820 nM for all). BX-320 inhibits Akt and p70S6K1 phosphorylation in PC3 cells (IC₅₀s = 1-3 µM). It induces apoptosis in, and inhibits the growth of, MDA-MB-468 breast cancer cells (IC₅₀s = 0.5 and 0.6 µM, respectively), as well as inhibits cell growth in a panel of cancer cells (IC₅₀s = 0.12-1.2 µM). BX-320 (200 mg/kg) inhibits the growth of lung tumors in a LOX melanoma mouse model of blood-borne metastasis.

1.Feldman, R.I., Wu, J.M., Polokoff, M.A., et al.Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1J. Biol. Chem.280(20)19867-19874(2005)