A glucocorticoid
货号:ajcx24150
CAS:59198-70-8
分子式:C27H36F2O5
分子量：478.6
溶解度:DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Diflucortolone 21-valerate is a glucocorticoid.¹It has anti-inflammatory effects in a rat model of croton oil-induced ear edema when applied topically (ED₅₀= 9.7 µg/ml).²Diflucortolone 21-valerate (0.1%) also induces skin inflammation and thins the epidermis in hairless dogs following chronic topical administration and increases allergic- and non-allergic-mediated skin inflammation in mouse models of atopic dermatitis when applied topically prior to and following sensitization.^3,1Formulations containing diflucortolone 21-valerate have been used in the treatment of inflammatory or allergic skin conditions.

1.Igawa, K., Katayama, I., Minatohara, K., et al.Topical glucocorticoid augments both allergic and non-allergic cutaneous reactions in mice when applied at the afferent stage of contact sensitivityAllergol. Int.46(1)33-41(1997) 2.Yamada, K., Hattori, S., Hakoda, T., et al.A fundamental study on a bioassay for the antiphlogistic effect of topically applied antiinflammatory agentsNihon Yakurigaku Zasshi75(8)789-798(1979) 3.Kimura, T., and Doi, K.Dorsal skin reactions of hairless dogs to topical treatment with corticosteroidsToxicol. Pathol.27(5)528-535(1999)