Background:

Conglobatin C1 is a bacterial metabolite that has been found inStreptomycesMST-91080 and has anticancer activity.¹It is cytotoxic to NS-1 mouse myeloma cells (IC₅₀= 1.05 µg/ml) but not NFF human fibroblasts (IC₅₀= >100 µg/ml).

1.Lacey, H.J., Booth, T.J., Vuong, D., et al.Conglobatins B-E: Cytotoxic analogues of the C2-symmetric macrodiolide conglobatinJ. Antibiot. (Tokyo)73(11)756-765(2020)