An active metabolite of ranolazine
货号:ajcx25776
CAS:5294-61-1
分子式:C14H21N3O
分子量：247.3
溶解度:DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 5 mg/ml,Ethanol: 5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CVT-2738 is an active metabolite of the antianginal agent ranolazine .¹It is formed from ranolazine by the cytochrome P450 (CYP) isoform CYP3A. CVT-2738 (100 mg/kg) inhibits increases in T-wave height and the RR interval in a mouse model of myocardial ischemia induced by isoprenaline .²

1.Wang, Y., Chen, X., Sun, Z., et al.Development and validation of a sensitive LC-MS/MS assay for simultaneous quantitation of ranolazine and its three metabolites in human plasmaJ. Chromatogr. B889-89010-16(2012) 2.Yao, Z., Gong, S., Guan, T., et al.Synthesis of ranolazine metabolites and their anti-myocardial ischemia activitiesChem. Pharm. Bull. (Tokyo)57(11)1218-1222(2009)