NSC 756093 是一种有效的 GBP1:PIM1 相互作用抑制剂。 NSC 756093 可以潜在地恢复对紫杉醇的耐药性。 NSC 756093 可用于卵巢癌研究。
货号:ajcx25780
CAS:1629908-92-4
分子式:C20H19NO4
分子量：337.4
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NSC 756093 is an inhibitor of the protein-protein interaction between guanylate binding protein 1 (GBP1) and the serine/threonine kinase Pim-1.¹It binds to GBP1-Pim-1 (K_d= 38 nM) and inhibits the interaction by 65% when used at a concentration of 100 nM. NSC 756093 enhances radiation-induced cytotoxicity in FaDu hypopharyngeal carcinoma cells (IC₅₀= 496 nM), as well as induces apoptosis and cell cycle arrest at the G₂/M phase in the same cells.²

1.Andreoli, M., Persico, M., Kumar, A., et al.Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cellsJ. Med. Chem.57(19)7916-7932(2014) 2.Resendez, A., Tailor, D., Graves, E., et al.Radiosensitization of head and neck squamous cell carcinoma (HNSCC) by a podophyllotoxinACS Med. Chem. Lett.10(9)1314-1321(2019)