您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > p-Cresol Glucuronide
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
p-Cresol Glucuronide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
p-Cresol Glucuronide图片
规格:98%
分子量:284.3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
A metabolite of p-cresol
货号:ajcx25784
CAS:17680-99-8
分子式:C13H16O7
分子量:284.3
溶解度:Ethanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

p-Cresol glucuronide is a metabolite ofp-cresol, a uremic toxin formed by bacterial fermentation of proteins in the large intestine.1It is formed fromp-cresol primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A6, but also by UGT1A9, in human liver and kidney microsomes.p-Cresol glucuronide accumulates in feces, blood, and urine of patients with chronic kidney disease (CKD).2


1.Rong, Y., and Kiang, T.K.L.Characterizations of human UDP-glucuronosyltransferase enzymes in the conjugation of p-cresolToxicol. Sci.176(2)285-296(2020) 2.Gryp, T., De Paepe, K., Vanholder, R., et al.Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney diseaseKidney Int.97(6)1230-1242(2020)