A taurine-conjugated form of ursodeoxycholic acid
货号:ajcx25824
CAS:N/A
分子式:C26H44NO6S·Na [XH2O]
分子量：521.7
溶解度:DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tauroursodeoxycholic acid (TUDCA) is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid .^1,2TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears.²It demonstrates anti-apoptotic activity in rodent models of tauopathy, Huntington’s disease, ischemic brain injury, and retinal disorders.^3,2

1.Beuers, U.Effects of bile acids on hepatocellular signaling and secretionYale J. Biol. Med.70(4)341-346(1997) 2.Boatright, J.H., Nickerson, J.M., Moring, A.G., et al.Bile acids in treatment of ocular diseaseJ. Ocul. Biol. Dis. Infor.2(3)149-159(2009) 3.Vang, S., Longley, K., Steer, C.J., et al.The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseasesGlob. Adv. Health Med.3(3)58-69(2014)