An internal standard for the quantification of phenformin
货号:ajcx26006
CAS:N/A
分子式:C10H10D5N5 • HCl
分子量：246.8
溶解度:DMF: 33 mg/mL,DMSO: 33 mg/mL,Ethanol: 10 mg/mL,PBS (pH 7.2): 5mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Phenformin-d₅is intended for use as an internal standard for the quantification of phenformin by GC- or LC-MS. Phenformin is an antihyperglycemic biguanide.¹It reduces blood glucose levels in a mouse model of diabetes induced by alloxan when administered at a dose of 100 mg/kg. Phenformin (250 mg/kg) induces lactic acidosis in diabetic dogs.²It also inhibits tumor growth of MCF-7 and MDA-MB-231 breast cancer mouse xenograft models when administered at a dose of 300 mg/kg.³Formulations containing phenformin were previously used in the treatment of diabetes mellitus.

1.Li, W.-L., Wu, J.-L., Ren, B.-R., et al.Pharmacological studies on anti-hyperglycemic effect of folium eriobotryaeAm. J. Chin. Med.35(4)705-711(2007) 2.Arieff, A.I., Park, R., Leach, W.J., et al.Pathophysiology of experimental lactic acidosis in dogsAm. J. Physiol.239(2)F135-F142(1980) 3.Appleyard, M.V.C.L., Murray, K.E., Coates, P.J., et al.Phenformin as prophylaxis and therapy in breast cancer xenograftsBr. J. Cancer106(6)1117-1122(2012)