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Difethialone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Difethialone图片
包装:1mg
规格:98%
市场价:3773元
分子量:539.5

产品介绍
An anticoagulant rodenticide and a vitamin K antagonist
货号:ajcx26428
CAS:104653-34-1
分子式:C31H23BrO2S
分子量:539.5
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Difethialone is an anticoagulant rodenticide and a vitamin K antagonist.1It binds to vitamin K epoxide reductase (VKOR; Kis = 0.04 and 0.05 µM for the wild-type and VKORY139Fenzyme, respectively). Difethialone is toxic to mice (LD50= 1.29 mg/kg).2Formulations containing difethialone have been used in the control of rodent pest populations.

1.Hodroge, A., Longin-Sauvageon, C., Fourel, I., et al.Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulantsArch. Biochem. Biophys.515(1-2)14-20(2011) 2.Vandenbroucke, V., Bousquet-Melou, A., De Backer, P., et al.Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administrationJ. Vet. Pharmacol. Ther.31(5)437-445(2008)