LCS3 是一种可逆且非竞争性的谷胱甘肽二硫化物还原酶 (GSR) 和硫氧还蛋白还原酶 1 (TXNRD1) 抑制剂（IC50=3.3 μM 和 3.8 μM 分别）。 LCS3 显示出抗肿瘤活性，并诱导细胞凋亡。 LCS3 可用于肺腺癌 (LUAD) 研究。
货号:ajcx26434
CAS:109844-92-0
分子式:C11H7ClN2O4
分子量：266.6
溶解度:DMF: slightly,DMSO: 1 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LCS3 is an inhibitor of glutathione reductase (GR) and thioredoxin reductase (TrxR; IC₅₀s = 3.3 and 3.8 µM, respectively).¹It decreases the glutathione (GSH) to oxidized GSH (GSSG) ratio in NCI H1650 and H23 lung adenocarcinoma cells in a concentration-dependent manner. LCS3 (3 µM) induces apoptosis in NCI H1650 and H23 cells but not non-transformed HPL1D lung epithelial cells. It is also active againstM. tuberculosis(MIC = 0.098 µM).²

1.Johnson, F.D., Ferrarone, J., Liu, A., et al.Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cellsCell Rep.38(6)110343(2022) 2.Gallardo-Marcias, R., Kumar, P., Jaskowski, M., et al.Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agentBioorg. Med. Chem. Lett.29(4)601-606(2019)