L-Phenylalanine-13C6 ((S)-2-Amino-3-phenylpropionic acid-13C6) 是 13C 标记的 L-Phenylalanine。
货号:ajcx26488
CAS:180268-82-0
分子式:C3[13C]6H11NO2
分子量：171.2
溶解度:Water: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

L-Phenylalanine-¹³C₆is intended for use as an internal standard for the quantification of phenylalanine by GC- or LC-MS. L-Phenylalanine is an essential amino acid.^1,2,3Blood and brain levels of L-phenylalanine are increased and associated with progressive cognitive impairments, seizures, motor deficits, and autism in patients with phenylketonuria, an inborn error of metabolism characterized by mutations in the gene encoding phenylalanine hydroxylase (PAH). L-Phenylalanine inhibits NMDA-induced currents in primary rat hippocampal neurons (IC₅₀= 1.71 mM).¹It also assembles into fibrilsin vitrothat are cytotoxic to PC12 and CHO cells when used at concentrations ranging from 1.16 to 15 mM.²

1.Glushakov, A.V., Dennis, D.M., Morey, T.E., et al.Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuriaMol. Psychiatry7(4)359-367(2002) 2.Adler-Abramovich, L., Vaks, L., Carny, O., et al.Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuriaNat. Chem. Biol.8(8)701-706(2012) 3.Blau, N., van Spronsen, F.J., and Levy, H.L.PhenylketonuriaLancet376(9750)1417-1427(2010)