An oxidative metabolite of vitamin E
货号:ajcx26654
CAS:7559-04-8
分子式:C29H50O3
分子量：446.7
溶解度:DMF: 12 mg/mL,DMSO: 10 mg/mL,Ethanol: 16 mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

D-α-Tocopheryl quinone is an active oxidative metabolite of vitamin E and an essential cofactor for mitochondrial fatty acid desaturases.¹It has antioxidant activity in oxygen radical absorbance capacity (ORAC) and radical trapping assays when used at a concentration of 25 µM and inhibits ferroptosis induced by (1S,3R)-RSL3 in Q7 cells (EC₅₀= 0.233 µM).²D-α-Tocopheryl quinone (20 mg/kg) decreases serum malondialdehyde (MDA) and blood glucose levels and restores the number and diversity of intestinal microflora in a rat model of high cholesterol and cholate diet-induced non-alcoholic steatohepatitis (NASH).³

1.Infante, J.P.A function for the vitamin E metabolite alpha-tocopherol quinone as an essential enzyme cofactor for the mitochondrial fatty acid desaturasesFEBS Lett.446(1)1-5(1999) 2.Hinman, A., Holst, C.R., Latham, J.C., et al.Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.PLoS One13(8)e0201369(2018) 3.Sun, T., Zhang, B., Ru, Q.-J., et al.Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in ratsPharm. Biol.59(1)723-731(2021)