| 规格: | 98% |
| 分子量: | 448.48 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
Background:
Menin-MLL interaction inhibitor; binds menin (IC50 = 446 nM). Selectively inhibits proliferation and induces apoptosis of leukemia cells harboring MLL fusion proteins. Also blocks transformation and induces hematopoietic differentiation of MLL-AF9 transformed bone marrow cells.
Grembecka et al (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat.Chem.Biol. 8 277 PMID:22286128 |Phillips et al (2019) Target identification reveals lanosterol synthase as a vulnerability in glioma. Proc.Natl.Acad.Sci.U.S.A. 116 7957 PMID:30923116
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