Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells
货号:ajcx27712
CAS:1292285-54-1
分子式:C14H18N2O3
分子量：262.3
溶解度:DMSO: 100 mM,Ethanol: 100 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.

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