Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
货号:ajcx27758
CAS:N/A
分子式:C22H21FN4.3HCl
分子量：469.81
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Nuclear receptor-binding SET domain (NSD) 3 antagonist (IC50 = 1.2 μM). Selectively binds the PWWP1 domain of NSD3 (Kd = 166 nM). Antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells.

Böttcher et al (2019) Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol. 15 822 PMID:31285596