LEI-110 是 HRASLS 硫醇水解酶家族的有效、选择性和细胞渗透性泛抑制剂。
货号:ajcx28342
CAS:2313525-90-3
分子式:C25H23F3N2O3
分子量：456.5
溶解度:Ethanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LEI-110 is an inhibitor of adipose phospholipase A₂(AdPLA₂; IC₅₀= 100 nM).¹It also inhibits HRas-like suppressor 2 (HRASL2), retinoid acid receptor responder protein 3 (RARRES3), and calcium-independent N-acyltransferase (iNAT; IC₅₀s = 158, 158, and 25 nM, respectively). LEI-110 (10 µM) decreases arachidonic acid levels in U2OS cells expressing human AdPLA₂and prevents oleic acid-induced increases in lipid droplet formation in HepG2 cells.

1.Zhou, J., Mock, E.D., Martella, A., et al.Activity-based protein profiling identifies α-ketoamides as inhibitors for phospholipase A2 group XVIACS Chem. Biol.14(2)164-169(2019)